Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review

• Published in: Internal Medicine Vol. 62; no. 14; pp. 2063 - 2069
• Main Authors: Murawaki, Yoshiyuki, Yashima, Kazuo, Horie, Satoshi, Miura, Masahiko, Kato, Jun, Hirai, Takayuki, Takeda, Kazuki, Kono, Michimori, Yoshida, Manabu, Isomoto, Hajime
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 15.07.2023; Japan Science and Technology Agency
• Subjects: Adenocarcinoma; Adenocarcinoma - diagnosis; Adenocarcinoma - pathology; Atrophy; Case Report; differentiated gastric adenocarcinoma; Gastric Mucosa - pathology; Gastritis; Gastritis - diagnosis; Gastritis - pathology; gastrointestinal phenotype; Helicobacter Infections - complications; Helicobacter Infections - diagnosis; Helicobacter Infections - pathology; Helicobacter pylori; Helicobacter pylori-negative; Humans; Internal medicine; Literature reviews; Mucin; Mucosa; Phenotypes; Stomach Neoplasms - diagnosis; Stomach Neoplasms - pathology; differentiated gastric adenocarcinoma; Helicobacter pylori-negative; gastrointestinal phenotype
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.0246-22

A 46-year-old man was referred to our hospital for the examination of a flat elevated lesion with an erosion-like depression, located on the greater curvature of the antrum. Endoscopic submucosal dissection was performed. Histological findings of the resected specimen demonstrated a well-differentiated tubular adenocarcinoma with a diameter of 12 mm. No atrophy was observed in the tumor-adjacent mucosa. Serum Helicobacter pylori antibody estimation and 13C-urea breath tests yielded negative results. Immunohistochemical staining was positive for both gastric mucin and intestinal mucin. The final diagnosis was well-differentiated tubular adenocarcinoma with a gastrointestinal phenotype that originated in mucosa uninfected by H. pylori.