Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 36; pp. 13175 - 13180
• Main Authors: Fujino, Kan, Horie, Masayuki, Honda, Tomoyuki, Merriman, Dana K., Tomonaga, Keizo
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 09.09.2014; National Acad Sciences
• Subjects: Amino Acid Sequence; Amino acids; Animals; Base Sequence; Biological Sciences; Borna Disease - transmission; Borna Disease - virology; Borna disease virus; Borna disease virus - physiology; Cell lines; Cercopithecus aethiops; Conserved Sequence - genetics; DNA; DNA-Directed DNA Polymerase - metabolism; evolution; genome; Genome - genetics; Genomes; HEK293 Cells; hosts; Humans; Infections; Molecular Sequence Data; Mononegavirales; Protein Structure, Tertiary; Proteins; Replicon - genetics; Retroviridae; Retrovirus; Ribonucleoproteins - metabolism; RNA; Sciuridae; Sciuridae - genetics; Sciuridae - virology; Small mammals; Spermophilus; Transfection; Vero Cells; vertebrates; Viral Proteins - chemistry; Viral Proteins - metabolism; virus replication; Virus Replication - genetics; Viruses; antiviral immunity; endogenous nonretroviral viruses

Significance Sequences derived from ancient viruses have been shown to make up a substantial part of animal genomes. Bornaviruses, a genus of nonsegmented, negative-sense RNA virus, also have left their DNA copies in the genomes of a number of vertebrate lineages. Recent studies have demonstrated th...