MicroRNAs, fibrotic remodeling, and aortic aneurysms

• Published in: The Journal of clinical investigation Vol. 122; no. 2; pp. 490 - 493
• Main Author: Milewicz, Dianna M.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.02.2012
• Subjects: Analysis; Aneurysm, Ruptured - prevention & control; Animals; Aortic Aneurysm, Abdominal - therapy; Aortic aneurysms; Atherosclerosis; Biomedical research; Cardiovascular disease; Collagen; Coronary vessels; Development and progression; Fibroblasts; Gene expression; Genetic aspects; Humans; Hypertension; Ischemia; Kinases; Male; MicroRNA; MicroRNAs; MicroRNAs - antagonists & inhibitors; MicroRNAs - metabolism; Mutation; Physiological aspects; Risk factors; Transforming growth factors; United States

Aortic aneurysms are a common clinical condition that can cause death due to aortic dissection or rupture. The association between aortic aneurysm pathogenesis and altered TGF-β signaling has been the subject of numerous investigations. Recently, a TGF-β-responsive microRNA (miR), miR-29, has been i...