MicroRNAs, fibrotic remodeling, and aortic aneurysms

Aortic aneurysms are a common clinical condition that can cause death due to aortic dissection or rupture. The association between aortic aneurysm pathogenesis and altered TGF-β signaling has been the subject of numerous investigations. Recently, a TGF-β-responsive microRNA (miR), miR-29, has been i...

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Bibliographic Details
Published inThe Journal of clinical investigation Vol. 122; no. 2; pp. 490 - 493
Main Author Milewicz, Dianna M.
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.02.2012
Subjects
Analysis
Aneurysm, Ruptured - prevention & control
Animals
Aortic Aneurysm, Abdominal - therapy
Aortic aneurysms
Atherosclerosis
Biomedical research
Cardiovascular disease
Collagen
Coronary vessels
Development and progression
Fibroblasts
Gene expression
Genetic aspects
Humans
Hypertension
Ischemia
Kinases
Male
MicroRNA
MicroRNAs
MicroRNAs - antagonists & inhibitors
MicroRNAs - metabolism
Mutation
Physiological aspects
Risk factors
Transforming growth factors
United States
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Summary:Aortic aneurysms are a common clinical condition that can cause death due to aortic dissection or rupture. The association between aortic aneurysm pathogenesis and altered TGF-β signaling has been the subject of numerous investigations. Recently, a TGF-β-responsive microRNA (miR), miR-29, has been identified to play a role in cellular phenotypic modulation during aortic development and aging. In this issue of JCI, Maegdefessel and colleagues demonstrate that decreasing the levels of miR-29b in the aortic wall can attenuate aortic aneurysm progression in two different mouse models of abdominal aortic aneurysms. This study highlights the relevance of miR-29b in aortic disease but also raises questions about its specific role.
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ISSN:0021-9738
1558-8238
1558-8238
DOI:10.1172/JCI62204