Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection

• Published in: The Journal of clinical investigation Vol. 121; no. 7; pp. 2534 - 2542
• Main Authors: Jones, Dallas, Glimcher, Laurie H., Aliprantis, Antonios O.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.07.2011
• Subjects: Animals; Arthritis; Arthritis - drug therapy; Arthritis - immunology; Biomedical research; Bisphosphonates; Cartilage; Cytokines; Development and progression; Enzymes; Humans; Immune response; Immune System - immunology; Infection - immunology; Inflammation; Interleukin-17 - immunology; Lymphocytes; Neoplasms - drug therapy; Neoplasms - immunology; Osteoblasts - immunology; Osteoclasts - immunology; Osteoporosis; Osteoporosis - drug therapy; Osteoporosis - immunology; Physiological aspects; RANK Ligand - immunology; Science in Medicine; T cell receptors; United States
• ISSN: 0021-9738; 1558-8238; 1558-8238
• DOI: 10.1172/JCI46262

Over the past decade and a half, the biomedical community has uncovered a previously unappreciated reciprocal relationship between cells of the immune and skeletal systems. Work in this field, which has been termed "osteoimmunology," has resulted in the development of clinical therapeutics for seemingly disparate diseases linked by the common themes of inflammation and bone remodeling. Here, the important concepts and discoveries in osteoimmunology are discussed in the context of the diseases bridging these two organ systems, including arthritis, osteoporosis, cancer, and infection, and the targeted treatments used by clinicians to combat them.