When It Is Better to Regress: Dynamics of Vascular Pruning

• Published in: PLoS biology Vol. 13; no. 5; p. e1002148
• Main Authors: Ricard, Nicolas, Simons, Michael
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2015; Public Library of Science (PLoS)
• Subjects: Angiogenesis; Animals; Apoptosis; Biology; Blood vessels; Blood Vessels - growth & development; Cell adhesion & migration; Heart attacks; Ligands; Methods; Physiological aspects; Physiological research; Primer; Studies; Vascular endothelial growth factor; Vascular Remodeling; Veins & arteries

Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins,...