When It Is Better to Regress: Dynamics of Vascular Pruning

Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins,...

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Bibliographic Details
Published inPLoS biology Vol. 13; no. 5; p. e1002148
Main Authors Ricard, Nicolas, Simons, Michael
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.05.2015
Public Library of Science (PLoS)
Subjects
Angiogenesis
Animals
Apoptosis
Biology
Blood vessels
Blood Vessels - growth & development
Cell adhesion & migration
Heart attacks
Ligands
Methods
Physiological aspects
Physiological research
Primer
Studies
Vascular endothelial growth factor
Vascular Remodeling
Veins & arteries
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Summary:Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression.
Bibliography:ObjectType-Article-1
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The authors have declared that no competing interests exist.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.1002148