When It Is Better to Regress: Dynamics of Vascular Pruning

Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins,...

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Published inPLoS biology Vol. 13; no. 5; p. e1002148
Main Authors Ricard, Nicolas, Simons, Michael
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.05.2015
Public Library of Science (PLoS)
Subjects
Angiogenesis
Animals
Apoptosis
Biology
Blood vessels
Blood Vessels - growth & development
Cell adhesion & migration
Heart attacks
Ligands
Methods
Physiological aspects
Physiological research
Primer
Studies
Vascular endothelial growth factor
Vascular Remodeling
Veins & arteries
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Abstract Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression.
AbstractList Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression.
Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression.Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression.
Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression. Blood vessel pruning is an important step in formation and maintenance of effective vascular networks; this Primer assesses two recent papers in PLOS Biology that explore molecular mechanisms of blood vessel regression.
  Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression.
Audience Academic
Author Simons, Michael
Ricard, Nicolas
AuthorAffiliation Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
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Copyright COPYRIGHT 2015 Public Library of Science
2015 Ricard, Simons 2015 Ricard, Simons
2015 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Ricard N, Simons M (2015) When It Is Better to Regress: Dynamics of Vascular Pruning. PLoS Biol 13(5): e1002148. doi:10.1371/journal.pbio.1002148
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Snippet Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of...
  Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of...
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StartPage e1002148
SubjectTerms Angiogenesis
Animals
Apoptosis
Biology
Blood vessels
Blood Vessels - growth & development
Cell adhesion & migration
Heart attacks
Ligands
Methods
Physiological aspects
Physiological research
Primer
Studies
Vascular endothelial growth factor
Vascular Remodeling
Veins & arteries
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Title When It Is Better to Regress: Dynamics of Vascular Pruning
URI https://www.ncbi.nlm.nih.gov/pubmed/25978860
https://www.proquest.com/docview/1681913238
https://pubmed.ncbi.nlm.nih.gov/PMC4433099
https://doaj.org/article/3ddba148055748098f758d8f5649876d
http://dx.doi.org/10.1371/journal.pbio.1002148
Volume 13
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