Kitamycins, New Antimycin Antibiotics Produced by Streptomyces sp

• Published in: Journal of antibiotics Vol. 52; no. 3; pp. 325 - 328
• Main Authors: HAYASHI, KEN-ICHIRO, NOZAKI, HIROSHI
• Format: Journal Article
• Language: English
• Published: TOKYO JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1999; JAPAN ANTIBIOT RES ASSN; Japan Antibiotics Research Association
• Subjects: Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antimycin A - analogs & derivatives; Antimycin A - biosynthesis; Antimycin A - chemistry; Antimycin A - pharmacology; Applied microbiology; Biological and medical sciences; Biotechnology & Applied Microbiology; Candida albicans - drug effects; Fundamental and applied biological sciences. Psychology; Gas Chromatography-Mass Spectrometry; Immunology; Lactuca - drug effects; Lactuca - growth & development; Life Sciences & Biomedicine; Macrolides; Magnetic Resonance Spectroscopy; Microbiology; Pharmacology & Pharmacy; Plant Growth Regulators - biosynthesis; Plant Growth Regulators - chemistry; Plant Growth Regulators - pharmacology; Science & Technology; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet; Streptomyces; Streptomyces - metabolism; Growth inhibitor; Insulation; Streptomycetaceae; Molecular structure; Streptomyces; In vitro; Biological activity; Actinomycetales; Antibiotic; Lettuce; Plant; Bacteria; Actinomycetes
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.52.325

In the course of our screening program for plant growth inhibitors, Streptomyces sp. K385 isolated from a soil sample collected in Okayama Japan, was found to produce kitamycin A (1) and B (2), new antimycin type antibiotics, together with known antimycin type antibiotics, antimycin A sub(1), A sub(2a), A sub(3), A sub(4a), urauchimycin B (3), and deisovalerylblastmycin (4). This study describes the fermentation, isolation, structure elucidation and biological activity of 1 and 2 and stereochemistry of 3.