Prevalence and incidence of non-gout crystal arthropathy in southern Sweden

• Published in: Arthritis research & therapy Vol. 21; no. 1; p. 291
• Main Authors: Hameed, Mohaned, Turkiewicz, Aleksandra, Englund, Martin, Jacobsson, Lennart, Kapetanovic, Meliha C
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.12.2019; BioMed Central; BMC
• Subjects: Age; ankh; Arthritis; association; Calcium phosphate; Calcium pyrophosphate crystal deposition; Calcium pyrophosphate crystal deposition disease (CPPD); Chondrocalcinosis; Clinical Medicine; Codes; deposition; Disease; disease (CPPD); Education; epidemiology; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; Gout; Health care; Health Sciences; Hydroxyapatite; Hydroxyapatites; Hälsovetenskap; Incidence; Klinisk medicin; knee chondrocalcinosis; Medical and Health Sciences; Medicin och hälsovetenskap; Non-gout crystal arthropathy; Occupations; osteoarthritis; Phosphates; Physicians; Prevalence; Primary care; Public Health, Global Health, Social Medicine and Epidemiology; Reumatologi och inflammation; Rheumatology; Rheumatology and Autoimmunity; risk; Socioeconomic factors; Unspecified non-gout crystal deposition disease; Canada; Sweden; Non-gout crystal arthropathy; Calcium pyrophosphate crystal deposition disease (CPPD); Prevalence; Unspecified non-gout crystal deposition disease; Incidence
• ISSN: 1478-6362; 1478-6354; 1478-6362
• DOI: 10.1186/s13075-019-2077-6

To estimate the prevalence and incidence of non-gout crystal arthropathy in relation to socioeconomic factors in southern Sweden. All patients (age ≥ 18 years) with at least one visit to a physician with the diagnosis of interest in the Skåne region (population of 1.3 million) in 1998-2014 were identified. Non-gout crystal arthropathy (ICD-10 codes M11.0-M11.9) was subclassified in four different groups: calcium pyrophosphate crystal deposition related arthropathy (CPPD), unspecified non-gout arthropathies, chondrocalcinosis, and hydroxyapatite crystal deposition disease. The crude and age-adjusted point prevalence on December 31, 2014, and the cumulative incidence during 2014 were calculated for all non-gout crystal arthropathies, CPPD, and other unspecified non-gout arthropathies overall and in relation to occupation, income, and level of education. The crude 2014 point prevalence (95% CI) and 2014 cumulative incidence (95% CI) of all non-gout crystal arthropathies were 0.23% (0.23-0.24) and 21.5 (19-25) cases/100,000 persons. Mean age (range) among all prevalent cases in 2014 was 71 (20-102) years and 56% were males. The point prevalence and cumulative incidence of CPPD were 0.09% (0.08-0.09) and 8 (7-10)/100,000 persons, respectively. The corresponding data for unspecified non-gout crystal deposition disease was 0.16% (0.16-0.17) and 15.6 (13-18)/100,000 persons, respectively. The prevalence and incidence of CPPD and unspecified non-gout crystal arthropathies were slightly higher in men and increased with age irrespective of gender. Unspecified non-gout crystal arthropathy but not CPPD was less prevalent in persons with ≥ 15 years of education, whereas there were no clear associations with occupation and income. The prevalence of all diagnosed non-gout crystal arthropathies was 0.23%, thus considerably less prevalent than gout in southern Sweden. CPPD and other unspecified non-gout crystal arthropathies are the predominant diagnoses, increasing with age and in men. With the exception for unspecified non-gout crystal arthropathies being inversely correlated to a higher level of education, no convincing association with the socioeconomic factors was found.