Neutrophils in tissue injury and repair

As one of the first defenders of innate immune response, neutrophils make a rapid and robust response against infection or harmful agents. While traditionally regarded as suicidal killers that cause collateral tissue damage, recent findings on neutrophil extracellular trap formation, heterogeneity a...

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Bibliographic Details
Published inCell and tissue research Vol. 371; no. 3; pp. 531 - 539
Main Author Wang, Jing
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2018
Springer
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Health aspects
Homeostasis
Human Genetics
Immune response
Innate immunity
Leukocytes (neutrophilic)
Molecular Medicine
Neutrophils
plasticity
Proteomics
Review
tissue repair
Regeneration
Angiogenesis
Repair
Injury
Neutrophils
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Summary:As one of the first defenders of innate immune response, neutrophils make a rapid and robust response against infection or harmful agents. While traditionally regarded as suicidal killers that cause collateral tissue damage, recent findings on neutrophil extracellular trap formation, heterogeneity and plasticity and novel reparative functions have expanded our understanding of their diverse roles in health and disease. This review summarizes our current understanding of neutrophil-associated tissue injury, highlighting the emerging roles of neutrophil extracellular traps. This review will also focus on scrutinizing the roles of neutrophils in tissue repair and regeneration and will examine data on unexpected aspects of involvement of neutrophils in regulating normal tissue homeostasis.
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ISSN:0302-766X
1432-0878
1432-0878
DOI:10.1007/s00441-017-2785-7