Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein–Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2–Infected Individuals

• Published in: The Journal of infectious diseases Vol. 219; no. 11; pp. 1749 - 1754
• Main Authors: Karlsson, Ingrid, Tingstedt, Jeanette Linnea, Şahin, Gülşen Özkaya, Hansen, Mikkel, Szojka, Zsofia, Buggert, Marcus, Biague, Antonio, da Silva, Zacharias, Månsson, Fredrik, Esbjörnsson, Joakim, Norrgren, Hans, Medstrand, Patrik, Fomsgaard, Anders, Jansson, Marianne
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.06.2019
• Subjects: Antibodies; Antibodies, Neutralizing - immunology; Antibody-Dependent Cell Cytotoxicity - immunology; Basic Medicine; CD4-Positive T-Lymphocytes - metabolism; CD4-Positive T-Lymphocytes - virology; Clinical Medicine; Cross Reactions - immunology; Cytotoxicity; env Gene Products, Human Immunodeficiency Virus - immunology; Glycoproteins; Glycoproteins - immunology; HIV; HIV Antibodies - immunology; HIV Infections - immunology; HIV Infections - virology; HIV-1 - immunology; HIV-2 - immunology; HIV/AIDS; Human immunodeficiency virus; Humans; Immunologi inom det medicinska området; Immunologi inom det medicinska området (Här ingår: Cell- och immunterapi); Immunology in the medical area; Immunology in the Medical Area (including Cell and Immunotherapy); Infections; Infectious Medicine; Infektionsmedicin; Klinisk medicin; Major and Brief Reports; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Toxicity; HIV-1; HIV-1/HIV-2 dual infection; intertype cross-reactive; HIV-2; ADCC; anti-HIV antibodies
• ISSN: 0022-1899; 1537-6613; 1537-6613
• DOI: 10.1093/infdis/jiz001

Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)–targeted ADCC were frequently identified in HIV-2–infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.