Oxidative Photo-Decarboxylation in the Presence of Mesoporous Silicas

• Published in: Chemical & Pharmaceutical Bulletin Vol. 54; no. 11; pp. 1571 - 1575
• Main Authors: Itoh, Akichika, Kodama, Tomohiro, Masaki, Yukio, Inagaki, Shinji
• Format: Journal Article
• Language: English; Japanese
• Published: TOKYO The Pharmaceutical Society of Japan 2006; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Acetates - chemistry; Aldehydes - chemical synthesis; Aldehydes - chemistry; Amino Acids - chemistry; Carboxylic Acids - chemistry; Catalysis; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Decarboxylation; Ketones - chemical synthesis; Ketones - chemistry; Life Sciences & Biomedicine; mesoporous silica; Molecular Structure; Oxidation-Reduction; Pharmacology & Pharmacy; phenylacetic acid derivative; photo-decarboxylation; Photochemistry; Physical Sciences; Porosity; Science & Technology; Silicon Dioxide - chemistry; α-amino acid; α-hydroxycarboxylic acid; SYSTEM; PROPENE; LIGHT; ARYLACETIC ACIDS; MOLECULAR-SIEVES; DEPROTECTION; mesoporous silica; phenylacetic acid derivative; photo-decarboxylation; ALPHA-HYDROXYCARBOXYLIC ACIDS; alpha-amino acid; alpha-hydroxycarboxylic acid; FSM-16; PHOTODECARBOXYLATION; CARBOXYLIC-ACIDS
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.54.1571

FSM-16, a mesoporous silica, was found to catalyze oxidative photo-decarboxylation of α-hydroxy carboxylic acid, phenyl acetic acid derivatives and N-acyl-protected α-amino acids to afford the corresponding carbonyl compounds. Furthermore, FSM-16 proved to be re-usable by re-calcination at 450 °C after the reaction.