Three New Stereoisomers of Condensed Tannins from the Roots of Rosa multiflora

Three new stereoisomers of condensed tannins (1—3), and four known phenolic compounds (4—7) were isolated from the 80% acetone extract of the roots of Rosa multiflora Thunberg. The structures of these compounds were elucidated using 1D/2D NMR, high resolution (HR)-MS, and circular dichroism (CD) spe...

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Published inChemical & Pharmaceutical Bulletin Vol. 58; no. 9; pp. 1227 - 1231
Main Authors Park, Kwan Hee, Kim, Sung Kyu, Choi, Sun Eun, Kwon, Joo Hee, Oh, Myung Hwan, Lee, Min Won
Format Journal Article
LanguageEnglish
Japanese
Published TOKYO The Pharmaceutical Society of Japan 01.09.2010
Pharmaceutical Society of Japan
Pharmaceutical Soc Japan
Japan Science and Technology Agency
Subjects
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
Biphenyl Compounds - metabolism
Cell Line
Cell Survival - drug effects
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
condensed tannin
Free Radicals - metabolism
Life Sciences & Biomedicine
Macrophages - cytology
Macrophages - drug effects
Macrophages - immunology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Nitric Oxide - immunology
Pharmacology & Pharmacy
phlobatannin
Physical Sciences
Picrates - metabolism
Plant Roots - chemistry
Proanthocyanidins - chemistry
Proanthocyanidins - isolation & purification
Proanthocyanidins - pharmacology
profisetinidin
proguibourtinidin
Rosa - chemistry
Rosa multiflora
Science & Technology
Stereoisomerism
condensed tannin
proguibourtinidin
phlobatannin
PHLOBATANNINS
OLIGOMERIC FLAVANOIDS
Rosa multiflora
profisetinidin
CONSTITUENTS
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Summary:Three new stereoisomers of condensed tannins (1—3), and four known phenolic compounds (4—7) were isolated from the 80% acetone extract of the roots of Rosa multiflora Thunberg. The structures of these compounds were elucidated using 1D/2D NMR, high resolution (HR)-MS, and circular dichroism (CD) spectra. In order to evaluate their anti-oxidative and anti-inflammatory activities, their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and inhibitory activity on nitric oxide (NO) production were determined.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.58.1227