Synthesis and Oral Absorption of Hetacillin and Hetamoxicillin Labile Esters
Nine esters of hetacillin or hetamoxicillin were synthesized as ampicillin and amoxicillin derivatives with the aim of obtaining improved plasma levels after oral administration. Out of these esters, which are devoid of apparent toxic effects, the benzyloxymethyl ester of hetacillin (FI-5204) gave t...
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Published in | Chemical & pharmaceutical bulletin Vol. 35; no. 6; pp. 2366 - 2372 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Tokyo
The Pharmaceutical Society of Japan
1987
Maruzen Japan Science and Technology Agency |
Subjects | |
Online Access | Get full text |
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Summary: | Nine esters of hetacillin or hetamoxicillin were synthesized as ampicillin and amoxicillin derivatives with the aim of obtaining improved plasma levels after oral administration. Out of these esters, which are devoid of apparent toxic effects, the benzyloxymethyl ester of hetacillin (FI-5204) gave the best result and was chosen for subsequent studies. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0009-2363 1347-5223 |
DOI: | 10.1248/cpb.35.2366 |