On the Chemical Constituents of Dipsacus asper

• Published in: Chemical & Pharmaceutical Bulletin Vol. 55; no. 12; pp. 1677 - 1681
• Main Authors: Tian, Xiao-Yan, Wang, Ying-Hong, Liu, Hong-Yue, Yu, Shi-Shan, Fang, Wei-Shuo
• Format: Journal Article
• Language: English; Japanese
• Published: TOKYO The Pharmaceutical Society of Japan 01.12.2007; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Biological Assay; Carbohydrates - analysis; Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dipsacaceae - chemistry; Dipsacus asper; dipsanoside C; dipsanoside D; dipsanoside E; dipsanoside F; dipsanoside G; Drug Screening Assays, Antitumor; Humans; Hydroxybenzoates - chemistry; Hydroxybenzoates - isolation & purification; Iridoids - chemistry; Iridoids - isolation & purification; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Pharmacology & Pharmacy; Physical Sciences; Plant Roots - chemistry; Powders; Science & Technology; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet; dipsanoside G; Dipsacus asper; dipsanoside E; dipsanoside F; dipsanoside C; IRIDOID GLUCOSIDE; dipsanoside D
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.55.1677

Bioassay-guided fractionation of 95% EtOH extract from the roots of Dipsacus asper lead to the isolation of some phenolic acids (caffeic acid, 2,6-dihydroxycinnamic acid, vanillic acid, 2′-O-caffeoyl-D-glucopyranoside ester, and caffeoylquinic acid) as the major active components, and five new iridoid glucoside dimers (1—5) and one new iridoid glucoside monomer (6), other known iridoid glycosides loganin, cantleyoside, triplostoside A, lisianthioside, 6′-O-β-D-apiofuranosyl sweroside, as well as triterpenoids oleanic acid and akebiasaponin D. The structures of new compounds 1—6 were determined as dipsanosides C (1), D (2), E (3), F (4), G (5), and 3′-O-β-D-glucopyranosyl sweroside (6) by spectroscopic, including 1D and 2D NMR techniques, and chemical methods.