The Resolution of Helicobacter suis-associated Gastric Lesions after Eradication Therapy

A reddish depressed lesion was found in the corpus of the stomach of a 56-year-old man. Gastric biopsy showed no findings of mucosa-associated lymphoid tissue lymphoma, including lympho-epithelial lesions. A urea breath test, stool antigen test and serum IgG antibody to Helicobacter pylori test were...

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Published inInternal Medicine Vol. 57; no. 2; pp. 203 - 207
Main Authors Nakagawa, Satoru, Shimoyama, Tadashi, Nakamura, Masahiko, Chiba, Daisuke, Kikuchi, Hidezumi, Sawaya, Manabu, Chinda, Daisuke, Mikami, Tatsuya, Fukuda, Shinsaku
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2018
Japan Science and Technology Agency
Subjects
Amoxicillin
Biopsy
Case Report
Chronic infection
Endoscopy
Gastritis
Helicobacter suis
Immunoglobulin G
Immunohistochemistry
Infections
Internal medicine
Lesions
Lymphoma
Metronidazole
Mucosa
Mucosal-associated lymphoid tissue
Omeprazole
PCR
Polymerase chain reaction
Stomach
Urea
Helicobacter suis
PCR
immunohistochemistry
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Summary:A reddish depressed lesion was found in the corpus of the stomach of a 56-year-old man. Gastric biopsy showed no findings of mucosa-associated lymphoid tissue lymphoma, including lympho-epithelial lesions. A urea breath test, stool antigen test and serum IgG antibody to Helicobacter pylori test were negative. Magnifying endoscopy using narrow-band-imaging showed no malignant structures. Gastric biopsy specimens were subjected to immunohistochemistry and a polymerase chain reaction, which identified Helicobacter suis infection. Triple therapy with esomeprazole, metronidazole, and amoxicillin was administered for 10 days. Three months later, endoscopy showed the significant improvement of the lesion. H. suis infection should be considered in chronic gastritis patients without H. pylori infection.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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Correspondence to Dr.　Tadashi Shimoyama, tsimo-hki@umin.ac.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.8971-17