Successful Radiotherapy of Primary Malignant Peripheral Nerve Sheath Tumor of the Lung

• Published in: Internal Medicine Vol. 61; no. 6; pp. 883 - 886
• Main Authors: Yanagisawa, Katsuya, Nishie, Kenichi, Takahashi, Hidekazu, Sano, Kenji, Takei, Kazuyoshi, Yamamoto, Hiroshi, Koizumi, Tomonobu, Hanaoka, Masayuki
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 15.03.2022; Japan Science and Technology Agency
• Subjects: Aged; Biopsy; Case Report; Chemotherapy; Computed tomography; Cough; Doxorubicin; Doxorubicin - therapeutic use; Humans; Internal medicine; Lung; Lungs; Male; malignant peripheral nerve sheath tumor; Nerve Sheath Neoplasms - diagnostic imaging; Nerve Sheath Neoplasms - radiotherapy; Neurofibrosarcoma - radiotherapy; Peripheral nerves; Radiation therapy; radiotherapy; sarcoma; Sputum; Tomography, X-Ray Computed; Tumors; malignant peripheral nerve sheath tumor; radiotherapy; sarcoma
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.8143-21

A 71-year-old man presented with cough and bloody sputum. Computed tomography showed a mass in the lower lobe of the left lung. Histological findings in biopsy tissue revealed a malignant peripheral nerve sheath tumor (MPNST). The patient was diagnosed with primary lung MPNST based on a systemic examination. Although initial chemotherapy treatment with doxorubicin failed to control the disease, radiotherapy considerably shrank the tumor. Primary lung MPNSTs are rare, and there is no established treatment for inoperable cases. This case suggests that radiotherapy is a treatment option for primary lung MPNST.