Anthropogenic Transmission of SARS-CoV-2 from Humans to Lions, Singapore, 2021

In Singapore, 10 captive lions tested positive for SARS-CoV-2 by real-time PCR. Genomic analyses of nanopore sequencing confirmed human-to-animal transmission of the SARS-CoV-2 Delta variant. Viral genomes from the lions and zookeeper shared a unique spike protein substitution, S:A1016V. Widespread...

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Published inEmerging infectious diseases Vol. 29; no. 12; pp. 2550 - 2553
Main Authors Ip, Yin Cheong Aden, Tan, Adrian, Ong, Jasmine, Fernandez, Charlene Judith, Lau, Clara, Wong, Wai Kwan, Chang, Siow Foong, Yap, Him Hoo, Er, Kenneth B.H
Format Journal Article
LanguageEnglish
Published Atlanta U.S. National Center for Infectious Diseases 01.12.2023
Centers for Disease Control and Prevention
Subjects
Analysis
Animals
Anthropogenic Transmission of SARS-CoV-2 from Humans to Lions, Singapore, 2021
Causes of
COVID-19
COVID-19 vaccines
Delta variant
Disease transmission
Diseases
DNA sequencing
Endangered & extinct species
Endangered species
Feces
Genomes
Genomics
Health aspects
Human-animal relationships
Immunization
Infection
Infections
Lions
Medical research
Mutation
National parks
Nucleotide sequencing
Protection and preservation
Research Letter
respiratory infections
Risk factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Virus research
Viruses
Wildlife conservation
Zoo animals
zoonoses
Zoos
Singapore
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Summary:In Singapore, 10 captive lions tested positive for SARS-CoV-2 by real-time PCR. Genomic analyses of nanopore sequencing confirmed human-to-animal transmission of the SARS-CoV-2 Delta variant. Viral genomes from the lions and zookeeper shared a unique spike protein substitution, S:A1016V. Widespread SARS-CoV-2 transmission among humans can increase the likelihood of anthroponosis.
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Author contributions: C.L., J.O., and W.K.W. conducted the molecular diagnostic tests; Y.C.A.I. performed the nanopore sequencing for viral genome assembly. Y.C.A.I and A.T. performed data analyses. The figures and the manuscript draft were prepared by Y.C.A.I. with input from C.J.F. Study initiation and guidance was by K.B.H.E, and supervised by C.J.F., S.F.C., Y.H.H., and K.B.H.E. Y.C.A.I. wrote the manuscript and all authors contributed to the manuscript editing process, approved the final version for publication, and declared that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The ethical handling of animal subjects during the course of this research has been supervised and approved by National Parks Board, Singapore.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2912.221916