SYNTHESIS AND BIOLOGICAL EVALUATION OF A 4-FLUOROMETHYL MONOBACTAM ANALOG

The synthesis and in vitro antibacterial activity of (±)( cis)-3-[2-(2-aminothiazol-4-yl)-( Z)-2-methoxyiminoacetamido]-4-fluoromethyl-2-oxo-1-azetidinesulfonic acid, potassium salt are presented.

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Bibliographic Details
Published inJournal of antibiotics Vol. 36; no. 9; pp. 1201 - 1204
Main Authors SKOTNICKI, JERAULD S., COMMONS, THOMAS J., REES, RICHARD W., SPETH, JOHN L.
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1983
Japan Antibiotics Research Association
Subjects
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - toxicity
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Aztreonam
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gram-Negative Bacteria - drug effects
Indicators and Reagents
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Microbiology
Spectrophotometry, Infrared
Antibiotic
Chemical synthesis
In vitro
Analog
Biological activity
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Summary:The synthesis and in vitro antibacterial activity of (±)( cis)-3-[2-(2-aminothiazol-4-yl)-( Z)-2-methoxyiminoacetamido]-4-fluoromethyl-2-oxo-1-azetidinesulfonic acid, potassium salt are presented.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.36.1201