Pilot study for risk assessment of aspiration pneumonia based on oral bacteria levels and serum biomarkers

• Published in: BMC infectious diseases Vol. 19; no. 1; pp. 761 - 8
• Main Authors: Nishizawa, Tomotaka, Niikura, Yuichi, Akasaka, Keiichi, Watanabe, Masato, Kurai, Daisuke, Amano, Masako, Ishii, Haruyuki, Matsushima, Hidekazu, Yamashita, Naomi, Takizawa, Hajime
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.09.2019; BioMed Central; BMC
• Subjects: Albumin; Aspiration pneumonia; Bacteria; Bacterial count; Biological markers; Body mass index; Cancer; Cancer patients; Chemotherapy; Deglutition disorders; Elderly; Elderly patients; Evaluation research (Social action programs); Hospital patients; Hygiene; Lung cancer; Malnutrition; Oral health; Oral hygiene; Pneumonia; Prevention; Risk assessment; Risk factors; Toiletries industry; Aspiration pneumonia; Bacterial count; Oral hygiene
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-019-4327-2

Aspiration pneumonia is a serious problem among elderly patients; it is caused by many risk factors including dysphagia, poor oral hygiene, malnutrition, and sedative medications. The aim of this study was to define a convenient procedure to objectively evaluate the risk of aspiration pneumonia in the clinical setting. This prospective study included an aspiration pneumonia (AP) group, a community-acquired pneumonia (CAP) group, and a control (Con) group (patients hospitalized for lung cancer chemotherapy). We used the Oral Health Assessment Tool (OHAT), which assesses oral hygiene, and evaluated performance status, body mass index, serum albumin levels, substance P values in plasma, and oral bacterial counts. The oral health as assessed by the OHAT of the aspiration pneumonia group was significantly impaired compared with that of the CAP group and the control (5.13 ± 0.18, 4.40 ± 0.26, 3.90 ± 0.22, respectively; p < 0.05). The oral bacterial count in the aspiration pneumonia group (7.20 ± 0.11) was significantly higher than that in the CAP group (6.89 ± 0.12), consistent with the OHAT scores. Oral bacterial count was significantly reduced by oral care. OHAT and oral bacterial counts can be a tool to assess the requirement of taking oral care and other preventive procedures in patients at high risk of aspiration pneumonia.