Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

• Published in: Emerging infectious diseases Vol. 27; no. 12; pp. 3173 - 3175
• Main Authors: Valkenburg, Sophie A., Cheng, Samuel M.S., Hachim, Asmaa, Peiris, Malik, Nicholls, John
• Format: Journal Article
• Language: English
• Published: Atlanta U.S. National Center for Infectious Diseases 01.12.2021; Centers for Disease Control and Prevention
• Subjects: antigen; Antigens; Autopsies; Coronaviruses; COVID-19; Dead; Disease transmission; Host-virus relationships; Infections; Infectious diseases; infectious virus; K18 hACE2 mice; Lungs; Medical research; Physiological aspects; Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue; Research Letter; RT-PCR; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; TCID50; Virus research; Hong Kong, China; Hong Kong; China

The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA...