Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA...

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Bibliographic Details
Published inEmerging infectious diseases Vol. 27; no. 12; pp. 3173 - 3175
Main Authors Valkenburg, Sophie A., Cheng, Samuel M.S., Hachim, Asmaa, Peiris, Malik, Nicholls, John
Format Journal Article
LanguageEnglish
Published Atlanta U.S. National Center for Infectious Diseases 01.12.2021
Centers for Disease Control and Prevention
Subjects
antigen
Antigens
Autopsies
Coronaviruses
COVID-19
Dead
Disease transmission
Host-virus relationships
Infections
Infectious diseases
infectious virus
K18 hACE2 mice
Lungs
Medical research
Physiological aspects
Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
Research Letter
RT-PCR
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
TCID50
Virus research
Hong Kong, China
Hong Kong
China
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Summary:The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA copies declined by 48.2%.
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2712.211621