Monocyte Signal Transduction Receptors in Active and Latent Tuberculosis

• Published in: Clinical & developmental immunology Vol. 2013; no. 2013; pp. 1 - 15
• Main Authors: Chmiela, Magdalena, Rudnicka, Wiesława, Fol, Marek, Szpakowski, Piotr, Kowalewicz-Kulbat, Magdalena, Zawadzka, Joanna, Kielnierowski, Grzegorz, Janiszewska-Drobinska, Beata, Wlodarczyk, Marcin, Druszczyńska, Magdalena, Rudnicka, Karolina
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2013; Hindawi Limited
• Subjects: Adult; Aged; Biomarkers - metabolism; CD18 Antigens - metabolism; Disease Progression; Disease Susceptibility; Female; Gene expression; Hospitals; Humans; Immune system; Immunology; Latent Tuberculosis - diagnosis; Latent Tuberculosis - immunology; Lectins, C-Type - metabolism; Lung diseases; Lymphocyte Function-Associated Antigen-1 - metabolism; Male; Mannose Receptor; Mannose-Binding Lectins - metabolism; Middle Aged; Monocytes - immunology; Monocytes - microbiology; Mycobacterium; Prognosis; Receptors, Cell Surface - metabolism; Receptors, IgG - metabolism; Signal Transduction; Toll-Like Receptor 2 - metabolism; Tuberculosis; Young Adult
• ISSN: 2314-8861; 1740-2522; 2314-7156; 1740-2530
• DOI: 10.1155/2013/851452

The mechanisms that promote either resistance or susceptibility to TB disease remain insufficiently understood. Our aim was to compare the expression of cell signaling transduction receptors, CD14, TLR2, CD206, and β2 integrin LFA-1 on monocytes from patients with active TB or nonmycobacterial lung disease and healthy individuals with M.tb latency and uninfected controls to explain the background of the differences between clinical and subclinical forms of M.tb infection. A simultaneous increase in the expression of the membrane bound mCD14 receptor and LFA-1 integrin in patients with active TB may be considered a prodrome of breaking immune control by M.tb bacilli in subjects with the latent TB and absence of clinical symptoms.