The Dual Role of HLA-G in Cancer

We here review the current data on the role of HLA-G in cancer based on recent findings of an unexpected antitumor activity of HLA-G in hematological malignancies. For the past decade, HLA-G has been described as a tumor-escape mechanism favoring cancer progression, and blocking strategies have been...

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Bibliographic Details
Published inJournal of Immunology Research Vol. 2014; no. 2014; pp. 1 - 10
Main Authors Carosella, Edgardo D., LeMaoult, Joel, Moreau, Philippe, Rouas-Freiss, Nathalie
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2014
Hindawi Limited
Wiley
Subjects
Animals
Cancer
Cytokines
Development and progression
Gene Expression Regulation
Genetic aspects
Hematology
Histocompatibility antigens
HLA histocompatibility antigens
HLA-G Antigens - genetics
HLA-G Antigens - immunology
HLA-G Antigens - metabolism
Humans
Immune system
Immune Tolerance
Immunology
Lymphocytes
Medical prognosis
Metastasis
Neoplasms - genetics
Neoplasms - immunology
Neoplasms - metabolism
Physiological aspects
Receptors, Immunologic - metabolism
Review
Tumors
France
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Summary:We here review the current data on the role of HLA-G in cancer based on recent findings of an unexpected antitumor activity of HLA-G in hematological malignancies. For the past decade, HLA-G has been described as a tumor-escape mechanism favoring cancer progression, and blocking strategies have been proposed to counteract it. Aside from these numerous studies on solid tumors, recent data showed that HLA-G inhibits the proliferation of malignant B cells due to the interaction between HLA-G and its receptor ILT2, which mediates negative signaling on B cell proliferation. These results led to the conjecture that, according to the malignant cell type, HLA-G should be blocked or conversely induced to counteract tumor progression. In this context, we will here present (i) the dual role of HLA-G in solid and liquid tumors with special emphasis on (ii) the HLA-G active structures and their related ILT2 and ILT4 receptors and (iii) the current knowledge on regulatory mechanisms of HLA-G expression in tumors.
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Academic Editor: Fabio Morandi
ISSN:2314-8861
2314-7156
DOI:10.1155/2014/359748