An Improved Method for Synthesis of 4,4-Dimethylpyrazolone and Application to Dihydropyridazinone Ring Formation

An improved method for 4,4-dimethylpyrazolone synthesis with t-butylcarbazate was described. The applicability of this method to dihydropyridazinone formation was demonstrated. This method is useful for suppressing the side reaction caused by the high nucleophilicity of hydrazine.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 60; no. 2; pp. 267 - 269
Main Authors Ochiai, Koji, Kojima, Akihiko, Kohno, Yasushi
Format Journal Article
LanguageEnglish
Japanese
Published TOKYO The Pharmaceutical Society of Japan 2012
Pharmaceutical Society of Japan
Pharmaceutical Soc Japan
Japan Science and Technology Agency
Subjects
4,4-dimethylpyrazolone
Chemistry
Chemistry Techniques, Analytical
Chemistry, Medicinal
Chemistry, Multidisciplinary
dihydropyridazinone
Hydrazines - chemistry
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Pharmacology & Pharmacy
Physical Sciences
Pyrazolones - chemical synthesis
Pyrazolones - chemistry
Pyridazines - chemical synthesis
Pyridazines - chemistry
Science & Technology
t-butylcarbazate
t-butylcarbazate
PYRAZOLIDINONE
BETA-LACTAM
ACYLHYDRAZONES
MANNICH-TYPE REACTIONS
PYRAZOLONE DERIVATIVES
dihydropyridazinone
INHIBITORS
4,4-dimethylpyrazolone
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Summary:An improved method for 4,4-dimethylpyrazolone synthesis with t-butylcarbazate was described. The applicability of this method to dihydropyridazinone formation was demonstrated. This method is useful for suppressing the side reaction caused by the high nucleophilicity of hydrazine.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.60.267