Abnormal Degree Centrality of Bilateral Putamen and Left Superior Frontal Gyrus in Schizophrenia with Auditory Hallucinations： A Resting-state Functional Magnetic Resonance Imaging Study

• Published in: Chinese medical journal Vol. 128; no. 23; pp. 3178 - 3184
• Main Authors: Chen, Cheng, Wang, Hui-Ling, Wu, Shi-Hao, Huang, Huan, Zou, Ji-Lin, Chen, Jun, Jiang, Tian-Zi, Zhou, Yuan, Wang, Gao-Hua
• Format: Journal Article
• Language: English
• Published: China Medknow Publications Pvt Ltd 05.12.2015; Medknow Publications and Media Pvt. Ltd; Lippincott Williams & Wilkins Ovid Technologies; Neuropsychiatry Institution,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China%Department of Psychiatry,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China%Department of Radiology,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China%LIAMA Center for Computational Medicine,National Laboratory of Pattern Recognition,Institute of Automation,Chinese Academy of Sciences,Beijing 110016,China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Adult; Analysis; Auditory hallucinations; Auditory Hallucinations; Degree Centrality; Functional Magnetic Resonance Imaging; Resting-state; Schizophrenia; Behavior; Brain Mapping; Brain research; Diagnosis; Dopamine; Female; Gyrus Cinguli - pathology; Gyrus Cinguli - physiopathology; Hallucinations; Hallucinations - pathology; Hallucinations - physiopathology; Hospitals; Humans; Laboratories; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical imaging; Mental disorders; NMR; Nuclear magnetic resonance; Original; Patients; Psychiatry; Putamen - pathology; Putamen - physiopathology; Schizophrenia; Schizophrenia - pathology; Schizophrenia - physiopathology; Young Adult; 中心性; 功能磁共振成像; 功能网络; 成像分析; 核异常; 状态; 精神分裂症; 静息; Schizophrenia; Auditory Hallucinations; Resting-state; Functional Magnetic Resonance Imaging; Degree Centrality
• ISSN: 0366-6999; 2542-5641
• DOI: 10.4103/0366-6999.170269

Background： Dysconnectivity hypothesis of schizophrenia has been increasingly emphasized. Recent researches showed that this dysconnectivity might be related to occurrence of auditory hallucination （AH）. However, there is still no consistent conclusion. This study aimed to explore intrinsic dysconnectivity pattern of whole-brain functional networks at voxel level in schizophrenic with AH. Methods： Auditory hallucinated patients group （n = 42 APG）, no hallucinated patients group （n = 42 NPG） and normal controls （n = 84 NCs） were analyzed by resting-state functional magnetic resonance imaging. The functional connectivity metrics index （degree centrality [DC]） across the entire brain networks was calculated and evaluated among three groups. Results： DC decreased in the bilateral putamen and increased in the left superior frontal gyrus in all the patients. However, in APG. the changes of DC were more obvious compared with NPG. Symptomology scores were negatively correlated with the DC of bilateral putamen in all patients. AH score of APG positively correlated with the DC in left superior frontal gyrus but negatively correlated with the DC in bilateral putamen. Conclusion： Our findings corroborated that schizophrenia was characterized by functional dysconnectivity, and the abnormal DC in bilateral putamen and left superior frontal gyrus might be crucial in the occurrence of AH.