Effects of melatonin on Wi-Fi-induced oxidative stress in lens of rats

• Published in: Indian journal of ophthalmology Vol. 62; no. 1; pp. 12 - 15
• Main Authors: Tök, Levent, Nazıroğlu, Mustafa, Doğan, Salih, Kahya, Mehmet, Tök, Özlem
• Format: Journal Article
• Language: English
• Published: India Medknow Publications 01.01.2014; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Animals; Antioxidants; Antioxidants - pharmacology; astigmatism; Care and treatment; Cataracts; Cell cycle; corneal scars; corneoplastique; Crystalline lens; Disease Models, Animal; Electric properties; Electromagnetic Fields - adverse effects; electromagnetic ration; Enzymes; Free radicals; glutathione; Health aspects; Laboratory animals; Lasik; lens; Lens, Crystalline - drug effects; Lens, Crystalline - metabolism; Lipid peroxidation; Lipids; Male; Melatonin; Melatonin - pharmacology; Metabolites; Molecular weight; Original; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - radiation effects; Physiological aspects; pinguecula; premium cataract surgery; Proteins; pterygium; radial keratotomy; Radio frequency; Rats; Rats, Wistar; refractive complications; Rodents; Antioxidants; lens; glutathione; electromagnetic ration; oxidative stress
• ISSN: 0301-4738; 1998-3689
• DOI: 10.4103/0301-4738.126166

Introduction: Melatonin has been considered a potent antioxidant that detoxifies a variety of reactive oxygen species in many pathophysiological states of eye. The present study was designed to determine the effects of Wi-Fi exposure on the lens oxidant, antioxidant redox systems, as well as the possible protective effects of melatonin on the lens injury induced by electromagnetic radiation (EMR). Materials and Methods: Thirty-two rats were used in the current study and they were randomly divided into four equal groups as follows: First and second groups were cage-control and sham-control rats. Rats in third group were exposed to Wi-Fi (2.45 GHz) for duration of 60 min/day for 30 days. As in the third group, the fourth group was treated with melatonin. The one-hour exposure to irradiation in second, third and fourth took place at noon each day. Results: Lipid peroxidation levels in the lens were slightly higher in third (Wi-Fi) group than in cage and sham control groups although their concentrations were significantly (P < 0.05) decreased by melatonin supplementation. Glutathione peroxidase (GSH-Px) activity was significantly (P < 0.05) lower in Wi-Fi group than in cage and sham control groups although GSH-Px (P < 0.01) and reduced glutathione (P < 0.05) values were significantly higher in Wi-Fi + melatonin group than in Wi-Fi group. Conclusions: There are poor oxidative toxic effects of one hour of Wi-Fi exposure on the lens in the animals. However, melatonin supplementation in the lens seems to have protective effects on the oxidant system by modulation of GSH-Px activity.