Effects of tissue susceptibility on brain temperature mapping

• Published in: NeuroImage (Orlando, Fla.) Vol. 146; pp. 1093 - 1101
• Main Authors: Maudsley, Andrew A., Goryawala, Mohammed Z., Sheriff, Sulaiman
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2017; Elsevier Limited
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid - analogs & derivatives; Aspartic Acid - metabolism; Body Temperature; Brain - metabolism; Brain architecture; Brain Mapping; Brain research; Brain temperature; Calibration; Cerebellum; Cerebrum; Female; Gender; Hemispheric laterality; Human subjects; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetic susceptibility; Male; Metabolites; Methods; Middle Aged; MR spectroscopic imaging; N-Acetylaspartate; Neuroimaging; Software; Substantia alba; Temperature; Temperature effects; Thermography; Tissue susceptibility; Young Adult; Aging; Brain temperature; MR spectroscopic imaging; Gender; Tissue susceptibility
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2016.09.062

A method for mapping of temperature over a large volume of the brain using volumetric proton MR spectroscopic imaging has been implemented and applied to 150 normal subjects. Magnetic susceptibility-induced frequency shifts in gray- and white-matter regions were measured and included as a correction in the temperature mapping calculation. Additional sources of magnetic susceptibility variations of the individual metabolite resonance frequencies were also observed that reflect the cellular-level organization of the brain metabolites, with the most notable differences being attributed to changes of the N-Acetylaspartate resonance frequency that reflect the intra-axonal distribution and orientation of the white-matter tracts with respect to the applied magnetic field. These metabolite-specific susceptibility effects are also shown to change with age. Results indicate no change of apparent brain temperature with age from 18 to 84 years old, with a trend for increased brain temperature throughout the cerebrum in females relative for males on the order of 0.1°C; slightly increased temperatures in the left hemisphere relative to the right; and a lower temperature of 0.3°C in the cerebellum relative to that of cerebral white-matter. This study presents a novel acquisition method for noninvasive measurement of brain temperature that is of potential value for diagnostic purposes and treatment monitoring, while also demonstrating limitations of the measurement due to the confounding effects of tissue susceptibility variations. [Display omitted] •Brain temperature can be mapped over a large volume using volumetric MR spectroscopic imaging.•The accuracy of the temperature measurement is impacted by local tissue susceptibility variations.•Spatial metabolite resonance frequency variation is due to molecular subcellular localization related susceptibility changes.•Mean temperature measurements reveal no differences with age, but small changes with gender and spatial location.