TCF7L2 Polymorphism rs7903146 Is Associated with Coronary Artery Disease Severity and Mortality

• Published in: PloS one Vol. 4; no. 11; p. e7697
• Main Authors: Sousa, André Gustavo P., Marquezine, Guilherme F., Lemos, Pedro A., Martinez, Eulogio, Lopes, Neuza, Hueb, Whady A., Krieger, José E., Pereira, Alexandre C.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.11.2009; Public Library of Science (PLoS)
• Subjects: Aged; Alleles; Analysis; Angina pectoris; Angioplasty; Arteriosclerosis; Atherosclerosis; Brackets; Cardiology; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Disorders/Coronary Artery Disease; Carriers; Catheterization; Coronary artery; Coronary artery disease; Coronary Artery Disease - genetics; Coronary Artery Disease - mortality; Coronary heart disease; Coronary vessels; Cross-Sectional Studies; Diabetes; Diabetes and Endocrinology; Diabetes mellitus; Diabetes Mellitus, Type 2 - genetics; Diabetics; Family medical history; Female; Gene Expression Regulation; Gene polymorphism; Genetic aspects; Genetic Predisposition to Disease; Genetics; Genetics and Genomics/Complex Traits; Genotype; Genotypes; Haplotypes; Health aspects; Health risk assessment; Health risks; Heart attacks; Humans; Hyperglycemia; Incidence; Intubation; Laboratories; Lesions; Male; Medical research; Medical schools; Middle Aged; Mortality; Patients; Polymorphism; Population studies; Populations; Prevalence; Risk; Risk factors; Studies; Surgery; TCF Transcription Factors - genetics; TCF Transcription Factors - physiology; Transcription Factor 7-Like 2 Protein; Type 2 diabetes; Brazil
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0007697

TCF7L2 polymorphisms have been consistently associated with type 2 diabetes mellitus in different populations and type 2 diabetes mellitus is a major risk factor for cardiovascular disease, especially coronary artery disease. This study aimed to evaluate the association between TCF7L2 polymorphism rs7903146 and coronary artery disease in diabetic and non-diabetic subjects. two populations were studied in order to assess severity of coronary artery disease and cardiovascular events incidence. Eight-hundred and eighty nine subjects who were referred for cardiac catheterization for coronary artery disease diagnosis were cross-sectionally evaluated for coronary lesions (atherosclerotic burden) and 559 subjects from the MASS-II Trial were prospectively followed-up for 5 years and assessed for major cardiovascular events incidence. As expected, rs7903146 T allele was associated with diabetes. Although diabetic patients had a higher prevalence of coronary lesions, no association between TCF7L2 genotype and coronary lesions was found in this subgroup. However, non-diabetic individuals carrying the T allele were associated with a significantly higher frequency of coronary lesions than non-diabetic non-carriers of the risk allele (adjusted OR = 2.32 95%CI 1.27-4.24, p = 0.006). Moreover, presence of multi-vessel coronary artery disease was also associated with the CT or TT genotypes in non-diabetics. Similarly, from the prospective sample analysis, non-diabetics carrying the CT/TT genotypes had significantly more composite cardiovascular end-points events than CC carriers (p = 0.049), mainly due to an increased incidence of death (p = 0.004). rs7903146 T allele is associated with diabetes and, in non-diabetic individuals, with a higher prevalence and severity of coronary artery disease and cardiovascular events. name of registry site (see list below), registration number, trial registration URL in brackets. MEDICINE, ANGIOPLASTY, OR SURGERY STUDY (MASS II): Unique identifier: ISRCTN66068876.