Cancer-related circular RNA: diverse biological functions

Noncoding RNAs, including long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs), are involved in regulating biological functions. In recent decades, miRNAs and lncRNAs have both inspired a wave of research, but the study of circRNA functions is still in its infancy. Studies...

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Published inCancer cell international Vol. 21; no. 1; pp. 11 - 16
Main Authors Cheng, Dan, Wang, Jing, Dong, Zigang, Li, Xiang
Format Journal Article
LanguageEnglish
Published England BioMed Central 06.01.2021
BMC
Subjects
Adenosine
Back-splicing
Binding sites
Biogenesis
Bioinformatics
Biomarker
Biosynthesis
Cancer
CircRNAs
Circular RNA
Cytoplasm
Gene expression
miRNA
miRNA sponge
Proteins
Review
RNA polymerase
miRNA sponge
Biomarker
CircRNAs
Back-splicing
Biogenesis
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Summary:Noncoding RNAs, including long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs), are involved in regulating biological functions. In recent decades, miRNAs and lncRNAs have both inspired a wave of research, but the study of circRNA functions is still in its infancy. Studies have found that circRNAs actively participate in the occurrence and development of various diseases, which emphasizes the importance of circRNAs. Here, we review the features and classification of circRNAs and summarize their functions. Then, we briefly describe how to analyze circRNAs by bioinformatics procedures. In addition, the relationship between circRNAs and cancers is discussed with an emphasis on proving whether circRNAs can be potential biomarkers for the prognosis and diagnosis of cancer.
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ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-020-01703-z