Toward better control of classical swine fever in wild boars: susceptibility of boar-pig hybrids to a recent Japanese isolate and effectiveness of a bait vaccine

• Published in: Veterinary research (Paris) Vol. 51; no. 1; p. 96
• Main Authors: Fukai, Katsuhiko, Nishi, Tatsuya, Yamada, Manabu, Ikezawa, Mitsutaka
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.07.2020; BioMed Central; BMC
• Subjects: Animals; Antibodies; Antigens; bait vaccine; Classical Swine Fever - prevention & control; classical swine fever virus; Classical Swine Fever Virus - immunology; Crosses, Genetic; Epidemics; experimental infection; Feces; Fever; Hog cholera; Hogs; Hybridization, Genetic; Immunization; Infection; Infections; Japan; Life Sciences; Lymphatic system; Medical research; pathogenicity; Salmonella; Short Report; Spleen; Sus scrofa; Swine; Vaccination - veterinary; Vaccines; Viral Vaccines - immunology; Virulence; wild boars; Japan; Germany; bait vaccine; wild boars; classical swine fever virus; pathogenicity; experimental infection
• ISSN: 1297-9716; 0928-4249; 1297-9716
• DOI: 10.1186/s13567-020-00821-w

We analyzed the pathogenicity of a recent Japanese classical swine fever virus (CSFV) to wild boars via an experimental infection using boar-pig hybrids as an alternative to wild boars. We also investigated the effectiveness of a bait vaccine against the CSFV. Naïve boar-pig hybrids and pigs showed clinical signs such as fever, leucopenia, anorexia and conjunctivitis following the experimental infection. In contrast, the boar-pig hybrids administered the bait vaccine did not show any clinical signs. Our data indicated that boar-pig hybrids and domestic pigs have similar susceptibility to the recent Japanese CSFV. Additionally, the bait vaccine is effective against the CSFV.