Health related quality of life utility weights for economic evaluation through different stages of chronic kidney disease: a systematic literature review

• Published in: Health and quality of life outcomes Vol. 18; no. 1; p. 310
• Main Authors: Cooper, Jacie T, Lloyd, Andrew, Sanchez, Juan Jose Garcia, Sörstadius, Elisabeth, Briggs, Andrew, McFarlane, Phil
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.09.2020; BioMed Central; BMC
• Subjects: Adult; Analysis; Bias; Chronic kidney failure; Cost analysis; Cost benefit analysis; Cost-effectiveness; Cost-utility; Dialysis; Disease Progression; Economic aspects; Economics; EQ-5D; Female; Grey literature; HUI; Humans; Kidney diseases; Kidneys; Literature reviews; Male; Medical research; Outcome Assessment, Health Care - methods; Peritoneal dialysis; Pharmacology; Quality of Life; Renal Insufficiency, Chronic - economics; Renal Insufficiency, Chronic - psychology; Renal Insufficiency, Chronic - therapy; Review; SF-6D; Surveys and Questionnaires; Task forces; Technology assessment; Transplants & implants; Canada; United Kingdom > UK; United States > US; China; Spain; EQ-5D; Dialysis; SF-6D; Cost-effectiveness; HUI; Cost-utility; Transplant
• ISSN: 1477-7525; 1477-7525
• DOI: 10.1186/s12955-020-01559-x

A Task Force from the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) provides recommendations on how to systematically identify and appraise health state utility (HSU) weights for cost-effectiveness analyses. We applied these recommendations to conduct a systematic review (SR) to identify HSU weights for different stages of chronic kidney disease (CKD), renal replacement therapy (RRT) and complications. MEDLINE® and Embase were searched for interventional and non-interventional studies reporting HSU weights for patients with CKD stages 1-5 or RRT. As per ISPOR Task Force Guidance, study quality criteria, applicability for Health Technology Assessment (HTA) and generalisability to a broad CKD population were used to grade studies as either 1 (recommended), 2 (to be considered if there are no data from grade 1 studies) or 3 (not recommended). A total of 17 grade 1 studies were included in this SR with 51 to 1767 participants, conducted in the UK, USA, Canada, China, Spain, and multiple-countries. Health related quality of life (HRQL) instruments used in the studies included were EQ-5D-3L (10 studies), SF-6D (4 studies), HUI2/HUI3 (1 study), and combinations (2 studies). Although absolute values for HSU weights varied among instruments, HSU weights decreased with CKD severity in a consistent manner across all instruments. This SR identified HSU weights for a range of CKD states and showed that HRQL decreases with CKD progression. Data were available to inform cost-effectiveness analysis in CKD in a number of geographies using instruments acceptable by HTA agencies.