The Human Connectome Project: A data acquisition perspective

The Human Connectome Project (HCP) is an ambitious 5-year effort to characterize brain connectivity and function and their variability in healthy adults. This review summarizes the data acquisition plans being implemented by a consortium of HCP investigators who will study a population of 1200 subje...

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Published inNeuroImage (Orlando, Fla.) Vol. 62; no. 4; pp. 2222 - 2231
Main Authors Van Essen, D.C., Ugurbil, K., Auerbach, E., Barch, D., Behrens, T.E.J., Bucholz, R., Chang, A., Chen, L., Corbetta, M., Curtiss, S.W., Della Penna, S., Feinberg, D., Glasser, M.F., Harel, N., Heath, A.C., Larson-Prior, L., Marcus, D., Michalareas, G., Moeller, S., Oostenveld, R., Petersen, S.E., Prior, F., Schlaggar, B.L., Smith, S.M., Snyder, A.Z., Xu, J., Yacoub, E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2012
Elsevier Limited
Subjects
Aging
Behavior
Brain - anatomy & histology
Brain - physiology
Brain mapping
Brain Mapping - methods
Brain research
Connectivity
Connectome - methods
Data mining
Diffusion imaging
fMRI
Grants
Humans
Medical imaging
MEG/EEG
Neurosciences
Scanners
Studies
Twins
ADNI
WashU
3T
T-MEG
UMinn
INDI
Diffusion imaging
dMRI
DZ
SNR
NIRS
T2w
Behavior
SLU
WU-Minn
MZ
R-MEG
R-fMRI
TE
fMRI
HCP
RF
CMRR
T-fMRI
Connectivity
MEG/EEG
T1w
Twins
SIR
7T
PET
TR
EPI
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Summary:The Human Connectome Project (HCP) is an ambitious 5-year effort to characterize brain connectivity and function and their variability in healthy adults. This review summarizes the data acquisition plans being implemented by a consortium of HCP investigators who will study a population of 1200 subjects (twins and their non-twin siblings) using multiple imaging modalities along with extensive behavioral and genetic data. The imaging modalities will include diffusion imaging (dMRI), resting-state fMRI (R-fMRI), task-evoked fMRI (T-fMRI), T1- and T2-weighted MRI for structural and myelin mapping, plus combined magnetoencephalography and electroencephalography (MEG/EEG). Given the importance of obtaining the best possible data quality, we discuss the efforts underway during the first two years of the grant (Phase I) to refine and optimize many aspects of HCP data acquisition, including a new 7T scanner, a customized 3T scanner, and improved MR pulse sequences.
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2012.02.018