Green tea catechins inhibit microglial activation which prevents the development of neurological disorders

• Published in: Neural regeneration research Vol. 15; no. 10; pp. 1792 - 1798
• Main Authors: Farkhondeh, Tahereh, Pourbagher-Shahri, Ali, Ashrafizadeh, Milad, Folgado, Silvia, Rajabpour-Sanati, Ali, Khazdair, Mohammad, Samarghandian, Saeed
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.10.2020; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran; Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran%Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran%Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran%Department of Medical Sciences, Faculty of Medicine of Albacete, Centro Regional de Investigaciones Biomédicas (CRIB), University of Castilla-La Mancha, Albacete, Spain%Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Antioxidants; B cells; Catechin; catechins; green tea; microglia; neuroinflammation; neurological disease; Chemical properties; Cytokines; Development and progression; Disease; Diseases; Flavonoids; Free radicals; Green tea; Growth factors; Health aspects; Isoflavones; Kinases; Microglia; Nervous system diseases; Neurodegeneration; Neurological disorders; Neurons; Neurophysiology; Neurotoxicity; Peptides; Polyamines; Polyphenols; Prevention; Proteins; Review; Tea; Tea (Beverage); Tumor necrosis factor-TNF; Iran; United States > US; green tea; catechins; neuroinflammation; microglia; neurological disease

The over-activated microglial cells induce neuroinflammation which has the main role in neurological disorders. The over-activated microglia can disturb neuronal function by releasing inflammatory mediators leading to neuronal dysfunctions and death. Thus, inhibition of over-activated microglia may...