Green tea catechins inhibit microglial activation which prevents the development of neurological disorders

• Published in: Neural regeneration research Vol. 15; no. 10; pp. 1792 - 1798
• Main Authors: Farkhondeh, Tahereh, Pourbagher-Shahri, Ali, Ashrafizadeh, Milad, Folgado, Silvia, Rajabpour-Sanati, Ali, Khazdair, Mohammad, Samarghandian, Saeed
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.10.2020; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran; Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran%Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran%Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran%Department of Medical Sciences, Faculty of Medicine of Albacete, Centro Regional de Investigaciones Biomédicas (CRIB), University of Castilla-La Mancha, Albacete, Spain%Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Antioxidants; B cells; Catechin; catechins; green tea; microglia; neuroinflammation; neurological disease; Chemical properties; Cytokines; Development and progression; Disease; Diseases; Flavonoids; Free radicals; Green tea; Growth factors; Health aspects; Isoflavones; Kinases; Microglia; Nervous system diseases; Neurodegeneration; Neurological disorders; Neurons; Neurophysiology; Neurotoxicity; Peptides; Polyamines; Polyphenols; Prevention; Proteins; Review; Tea; Tea (Beverage); Tumor necrosis factor-TNF; Iran; United States > US; green tea; catechins; neuroinflammation; microglia; neurological disease
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.280300

The over-activated microglial cells induce neuroinflammation which has the main role in neurological disorders. The over-activated microglia can disturb neuronal function by releasing inflammatory mediators leading to neuronal dysfunctions and death. Thus, inhibition of over-activated microglia may be an effective therapeutic approach for modulating neuroinflammation. Experimental studies have indicated anti-neuroinflammatory effects of flavonoids such as green tea catechins. The current research was aimed to review the effect of green tea catechins in inhibiting microglial cells, inflammatory cascades, and subsequent neurological diseases.