Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril

• Published in: BMC veterinary research Vol. 16; no. 1; p. 444
• Main Authors: Zhang, Keyu, Zheng, Haihong, Wei, Shuya, Wang, Xiaoyang, Fei, Chenzhong, Wang, Chunmei, Liu, Yingchun, Zhang, Lifang, Xue, Feiqun, Tang, Shusheng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.11.2020; BioMed Central; BMC
• Subjects: Administration, Oral; Animals; Beagle; Beagle dogs; Biochemistry; Care and treatment; chickens; Coccidiosis; Coccidiostats; Coccidiostats - administration & dosage; Coccidiostats - toxicity; diet; Dogs; Dosage; Dose-Response Relationship, Drug; Drug dosages; Drug withdrawal; Ethanamizuril; Evaluation; exhibitions; Feeding Behavior - drug effects; Feeds; Female; Food; Food consumption; Health aspects; Hematology; histology; Kidney - drug effects; Kidneys; Male; Mortality; Nephrotoxicity; no observed adverse effect level; Oral subchronic toxicity; Poultry; subchronic toxicity; Toxicity; Toxicity testing; Triazine; Triazine coccidiostats; triazines; Triazines - administration & dosage; Triazines - toxicity; turkeys; Urinalysis; veterinary medicine; China; Ethanamizuril; Oral subchronic toxicity; Triazine coccidiostats; Nephrotoxicity; Beagle dogs

Triazine coccidiostats are widely used in chickens and turkeys for coccidiosis control. Ethanamizuril is a novel triazine compound that exhibits anticoccidial activity in poultry. This study was designed to evaluate the subchronic toxicity of ethanamizuril in beagle dogs at doses of 12, 60 or 300 mg...