Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril

• Published in: BMC veterinary research Vol. 16; no. 1; p. 444
• Main Authors: Zhang, Keyu, Zheng, Haihong, Wei, Shuya, Wang, Xiaoyang, Fei, Chenzhong, Wang, Chunmei, Liu, Yingchun, Zhang, Lifang, Xue, Feiqun, Tang, Shusheng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.11.2020; BioMed Central; BMC
• Subjects: Administration, Oral; Animals; Beagle; Beagle dogs; Biochemistry; Care and treatment; chickens; Coccidiosis; Coccidiostats; Coccidiostats - administration & dosage; Coccidiostats - toxicity; diet; Dogs; Dosage; Dose-Response Relationship, Drug; Drug dosages; Drug withdrawal; Ethanamizuril; Evaluation; exhibitions; Feeding Behavior - drug effects; Feeds; Female; Food; Food consumption; Health aspects; Hematology; histology; Kidney - drug effects; Kidneys; Male; Mortality; Nephrotoxicity; no observed adverse effect level; Oral subchronic toxicity; Poultry; subchronic toxicity; Toxicity; Toxicity testing; Triazine; Triazine coccidiostats; triazines; Triazines - administration & dosage; Triazines - toxicity; turkeys; Urinalysis; veterinary medicine; China; Ethanamizuril; Oral subchronic toxicity; Triazine coccidiostats; Nephrotoxicity; Beagle dogs
• ISSN: 1746-6148; 1746-6148
• DOI: 10.1186/s12917-020-02655-2

Triazine coccidiostats are widely used in chickens and turkeys for coccidiosis control. Ethanamizuril is a novel triazine compound that exhibits anticoccidial activity in poultry. This study was designed to evaluate the subchronic toxicity of ethanamizuril in beagle dogs at doses of 12, 60 or 300 mg/kg/day in diet for 90 days. Ethanamizuril was well tolerated at low and middle dosages in beagle dogs, and no drug-related toxical effects were observaed in terms of survival, clinical observations, organs weight and damage in these dose groups. However, in high dose administration group, food consumption and histologic changes in kidneys were noticed in both sexes of beagle dog, although the renal lesions were finally resolved at the end of 4 weeks exposure of ethanamizuril. No-observed-adverse-effect level (NOAEL) was considered for ethanamizuril at dose of 60 mg/kg/day in Beagle dog. This result added toxicity effects of ethanamizuril to the safety database, which might guide safely using of ethanamizuril as a novel coccidiostat.