Systemic Correlates of Angiographic Coronary Artery Disease

• Published in: PloS one Vol. 4; no. 1; p. e4322
• Main Authors: Nunes, José Pedro L., Silva, João Carlos
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.01.2009; Public Library of Science (PLoS)
• Subjects: Acids; Acute coronary syndromes; Aged; Analysis; Anatomy; Angina pectoris; Angiography; Antilipemic agents; Arteriosclerosis; Atherosclerosis; Blood cholesterol; Blood Glucose - analysis; Body mass; Body Mass Index; Calcification; Calcium; Calcium - blood; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Disorders; Cardiovascular Disorders/Coronary Artery Disease; Cholesterol; Cholesterol - blood; Clinical trials; Coronary Angiography; Coronary artery; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - drug therapy; Coronary heart disease; Coronary vessels; Coronary Vessels - pathology; Correlation; Correlation analysis; Diabetes; Diabetes and Endocrinology; Diagnosis; Fasting; Female; Glomerular Filtration Rate; Glucose; Heart; Heart diseases; High density lipoprotein; Hospitals; Humans; Hyperglycemia; Independent variables; Insulin; Lesions; Linear Models; Lipids; Lipoproteins (high density); Lipoproteins (low density); Low density lipoprotein; Low density lipoproteins; Magnesium; Magnesium - blood; Male; Medical imaging; Medical research; Metabolism; Middle Aged; Obesity; Observation; Observational studies; Patients; Phosphorus; Phosphorus - blood; Plasmas (physics); Regression analysis; Risk Factors; Sex; Sex Factors; Smooth muscle; Statistics, Nonparametric; Stenosis; Trans fatty acids; Triglycerides; Triglycerides - blood; Type 2 diabetes; Uric acid; Uric Acid - blood
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0004322

Coronary angiography allows a direct evaluation of coronary anatomy. The aim of the present investigation was to search for correlations between the magnitude of coronary artery disease, as assessed by angiography, and a number of systemic parameters. A group of 116 patients (80 male, 36 female) with coronary heart disease diagnosed by angiography, aged 62.0+/-10.5 years, was the subject of an observational study. Correlation and linear regression analysis using coronary artery disease burden (CADB - sum of the percentage of the luminal stenosis encountered in all the lesions of the coronary arterial trees) as dependent variable, and age, sex, plasma calcium, phosphorus, magnesium, glucose, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, estimated glomerular filtration rate and body mass index as independent variables, were carried out. Significant correlation values versus CADB were seen with age (r 0.19, p 0.04), uric acid (r 0.18, p 0.048) and fasting plasma glucose (r 0.33, p<0.001). Linear regression analysis, yielding a global significance level of 0.002, showed a significant value for glucose (p 0.018) and for sex (0.008). In conclusion, among several systemic parameters studied, plasma glucose was found to be correlated to coronary artery atherosclerosis lesions.