Biomarkers for chronic kidney disease in dogs: a comparison study

The aim of this study was to determine whether serum symmetric dimethylarginine (SDMA) and cystatin C (CysC) levels can be utilized as more accurate markers of early kidney dysfunction in dogs. Forty-one client-owned dogs with chronic kidney disease (CKD), which were clinically stable, and ten beagl...

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Bibliographic Details
Published inJournal of Veterinary Medical Science Vol. 82; no. 8; pp. 1130 - 1137
Main Authors KIM, Joonyoung, LEE, Chang-Min, KIM, Ha-Jung
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2020
Japan Science and Technology Agency
The Japanese Society of Veterinary Science
Subjects
Animals
Arginine - analogs & derivatives
Arginine - blood
Biomarkers
Biomarkers - blood
Blood pressure
canine
creatinine
Cystatin C
Cystatin C - blood
Dog Diseases - blood
Dog Diseases - diagnosis
Dogs
Female
glomerular filtration rate
Internal Medicine
Kidney diseases
Male
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - veterinary
Sensitivity and Specificity
symmetric dimethylarginine
cystatin C
creatinine
canine
glomerular filtration rate
symmetric dimethylarginine
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Summary:The aim of this study was to determine whether serum symmetric dimethylarginine (SDMA) and cystatin C (CysC) levels can be utilized as more accurate markers of early kidney dysfunction in dogs. Forty-one client-owned dogs with chronic kidney disease (CKD), which were clinically stable, and ten beagles as healthy controls were included. All dogs underwent physical examination, systemic blood pressure measurement, complete blood cell count, and plasma biochemistry analyses. Frozen serum was used for SDMA and CysC analyses. Data analysis was performed using Kruskal Wallis, Pearson’s correlation, Bland-Altman plots, and receiver operating characteristic curve. SDMA and CysC levels were significantly higher in patients with CKD at various International Renal Interest Society (IRIS) stages than in the healthy controls. In particular, CysC level was the only biomarker that could indicate the earliest stage of CKD (IRIS stage I). Similar to these results, CysC level showed better sensitivity and specificity compared to the other biomarkers in early CKD dogs.
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ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.20-0125