Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update

• Published in: PloS one Vol. 4; no. 3; p. e4724
• Main Authors: Bennett, Diane E, Camacho, Ricardo J, Otelea, Dan, Kuritzkes, Daniel R, Fleury, Hervé, Kiuchi, Mark, Heneine, Walid, Kantor, Rami, Jordan, Michael R, Schapiro, Jonathan M, Vandamme, Anne-Mieke, Sandstrom, Paul, Boucher, Charles A B, van de Vijver, David, Rhee, Soo-Yon, Liu, Tommy F, Pillay, Deenan, Shafer, Robert W
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.03.2009; Public Library of Science (PLoS)
• Subjects: Anti-HIV Agents - pharmacology; Antiretroviral drugs; Criteria; Drug approval; Drug resistance; Drug Resistance, Viral - genetics; Drug therapy; Drugs; HIV; HIV Protease - genetics; HIV-1 - chemistry; HIV-1 - genetics; Human immunodeficiency virus; Infectious Diseases/Antimicrobials and Drug Resistance; Infectious Diseases/HIV Infection and AIDS; Mutation; Protease; Protease inhibitors; Proteases; Proteinase; Public Health and Epidemiology/Epidemiology; Public Health and Epidemiology/Infectious Diseases; RNA-Directed DNA Polymerase - genetics; Surveillance; Womens health; World Health Organization; Netherlands; Massachusetts; California
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0004724

Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs. To accurately compare transmitted drug resistance rates across geographic regions and times, the World Health Organization has recommended the adoption of a consensus genotypic definition of transmitted HIV-1 drug resistance. In January 2007, we outlined criteria for developing a list of mutations for drug-resistance surveillance and compiled a list of 80 RT and protease mutations meeting these criteria (surveillance drug resistance mutations; SDRMs). Since January 2007, several new drugs have been approved and several new drug-resistance mutations have been identified. In this paper, we follow the same procedures described previously to develop an updated list of SDRMs that are likely to be useful for ongoing and future studies of transmitted drug resistance. The updated SDRM list has 93 mutations including 34 NRTI-resistance mutations at 15 RT positions, 19 NNRTI-resistance mutations at 10 RT positions, and 40 PI-resistance mutations at 18 protease positions.