Distinguishing between different percolation regimes in noisy dynamic networks with an application to epileptic seizures

• Published in: PLoS computational biology Vol. 19; no. 6; p. e1011188
• Main Authors: Zhu, Xiaojing, Shappell, Heather, Kramer, Mark A, Chu, Catherine J, Kolaczyk, Eric D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2023; Public Library of Science (PLoS)
• Subjects: Algorithms; Analysis; Brain; Computer and Information Sciences; Convulsions & seizures; Electrodes; Epilepsy; Evolution; Hidden Markov models; Humans; Identification and classification; Markov chains; Markov processes; Medicine and Health Sciences; Nervous system; Networks; Neurosciences; Parameter estimation; Percolation; Phase Transition; Phase transitions; Physical Sciences; Research and Analysis Methods; Seizures; Seizures (Medicine); Time series; Italy
• ISSN: 1553-7358; 1553-734X; 1553-7358
• DOI: 10.1371/journal.pcbi.1011188

In clinical neuroscience, epileptic seizures have been associated with the sudden emergence of coupled activity across the brain. The resulting functional networks-in which edges indicate strong enough coupling between brain regions-are consistent with the notion of percolation, which is a phenomenon in complex networks corresponding to the sudden emergence of a giant connected component. Traditionally, work has concentrated on noise-free percolation with a monotonic process of network growth, but real-world networks are more complex. We develop a class of random graph hidden Markov models (RG-HMMs) for characterizing percolation regimes in noisy, dynamically evolving networks in the presence of edge birth and edge death. This class is used to understand the type of phase transitions undergone in a seizure, and in particular, distinguishing between different percolation regimes in epileptic seizures. We develop a hypothesis testing framework for inferring putative percolation mechanisms. As a necessary precursor, we present an EM algorithm for estimating parameters from a sequence of noisy networks only observed at a longitudinal subsampling of time points. Our results suggest that different types of percolation can occur in human seizures. The type inferred may suggest tailored treatment strategies and provide new insights into the fundamental science of epilepsy.