The Dynamic Roles of Mesenchymal Stem Cells in Colon Cancer

Colon cancer is still one of the most common causes of cancer in human and is characterized by lymphocyte infiltrates and originates from the epithelial cells found in the lining of colon or rectum of the gastrointestinal tract. Mesenchymal stem cells (MSCs) are composed of the multipotent stem cell...

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Published inCanadian journal of gastroenterology & hepatology Vol. 2018; no. 2018; pp. 1 - 8
Main Authors Wang, Yimin, Yang, Qiyuan, Miao, Zhiguo, Wang, Shan, Zhang, Jinzhou
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
Hindawi Limited
Wiley
Subjects
Antigens
Bone marrow
Cancer metastasis
Cancer therapies
Cell Differentiation
Colon - cytology
Colon - pathology
Colon cancer
Colonic Neoplasms - pathology
Colonic Neoplasms - therapy
Colorectal cancer
Development and progression
Efficiency
Fibroblasts
Gastrointestinal system
Health aspects
Humans
Lymphocytes
Mediation
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells - physiology
Metastasis
Review
Stem cells
Tumors
Umbilical cord
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Summary:Colon cancer is still one of the most common causes of cancer in human and is characterized by lymphocyte infiltrates and originates from the epithelial cells found in the lining of colon or rectum of the gastrointestinal tract. Mesenchymal stem cells (MSCs) are composed of the multipotent stem cell group of stroma and can be differentiated as various cell lineages, such as fibroblasts, osteoblasts, and adipocytes. MSCs provide mechanical and structural support and have potential functions during tumor growth and metastasis. The efficacy of MSC-based therapies is partly dependent on the migration and homing of MSCs to tumors and metastatic sites. However, their migratory and engraftment potential is poorly understood. In this review, the characteristics and mechanisms of MSC’s dynamic interaction with colon cancer were summarized, particularly the potential functions of MSCs on colon cancer, including its role in improving tumor growth and as a potential candidate for tumor therapy. Understanding MSC homing provides new insights into the manipulation of MSC and the improvement of their efficacy for colon cancer therapy.
Bibliography:Academic Editor: Salvatore Oliva
ISSN:2291-2789
2291-2797
DOI:10.1155/2018/7628763