Circular representation of human cortical networks for subject and population-level connectomic visualization

• Published in: NeuroImage (Orlando, Fla.) Vol. 60; no. 2; pp. 1340 - 1351
• Main Authors: Irimia, Andrei, Chambers, Micah C., Torgerson, Carinna M., Van Horn, John D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.04.2012; Elsevier Limited
• Subjects: Adult; Animal models; Brain - anatomy & histology; Brain Mapping - methods; Cerebral Cortex - anatomy & histology; Connectomics; Cortical network; Data processing; Diffusion Tensor Imaging; DTI; Humans; Magnetic Resonance Imaging; Male; Medical imaging; MRI; Nerve Net - anatomy & histology; Neuroimaging; NMR; Nuclear magnetic resonance; Population; Par; Neuroimaging; Fro; MPosCgG/S; MRI; SbCaG; IDA; NA-MIC; Connectomics; Ins; WM; TBI; Cortical network; LONI; GM; SupFG; NIH; Occ; fMRI; Lim; 3D; HCP; DTI; FA; Tem
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2012.01.107

Cortical network architecture has predominantly been investigated visually using graph theory representations. In the context of human connectomics, such representations are not however always satisfactory because canonical methods for vertex–edge relationship representation do not always offer optimal insight regarding functional and structural neural connectivity. This article introduces an innovative framework for the depiction of human connectomics by employing a circular visualization method which is highly suitable to the exploration of central nervous system architecture. This type of representation, which we name a ‘connectogram’, has the capability of classifying neuroconnectivity relationships intuitively and elegantly. A multimodal protocol for MRI/DTI neuroimaging data acquisition is here combined with automatic image segmentation to (1) extract cortical and non-cortical anatomical structures, (2) calculate associated volumetrics and morphometrics, and (3) determine patient-specific connectivity profiles to generate subject-level and population-level connectograms. The scalability of our approach is demonstrated for a population of 50 adults. Two essential advantages of the connectogram are (1) the enormous potential for mapping and analyzing the human connectome, and (2) the unconstrained ability to expand and extend this analysis framework to the investigation of clinical populations and animal models. ► A framework for visualization and exploration of human connectomics is introduced. ► This ‘connectogram’ representation has significant potential for connectomic analysis. ► Connectogram scalability is demonstrated using a population analysis of 50 adults.