Reactions of Difunctional Electrophiles with Functionalized Aryllithium Compounds: Remarkable Chemoselectivity by Flash Chemistry

Flash chemistry using flow microreactors enables highly chemoselective reactions of difunctional electrophiles with functionalized aryllithium compounds by virtue of extremely fast micromixing. The approach serves as a powerful method for protecting‐group‐free synthesis using organolithium compounds...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 54; no. 6; pp. 1914 - 1918
Main Authors Nagaki, Aiichiro, Imai, Keita, Ishiuchi, Satoshi, Yoshida, Jun-ichi
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 02.02.2015
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Chemistry
Chemistry, Multidisciplinary
chemoselectivity
flash chemistry
flow chemistry
Micromixing
Microreactors
Organolithium compounds
Physical Sciences
Science & Technology
Synthesis
chemoselectivity
ORGANIC-SYNTHESIS
REACTORS
CATALYZED ADDITION
ACIDS
ALDEHYDES
CHEMICAL SELECTIVITY
organolithium compounds
CARBONYLATION
SPACE INTEGRATION
microreactors
EFFICIENT
FLOW-MICROREACTOR APPROACH
flash chemistry
flow chemistry
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Summary:Flash chemistry using flow microreactors enables highly chemoselective reactions of difunctional electrophiles with functionalized aryllithium compounds by virtue of extremely fast micromixing. The approach serves as a powerful method for protecting‐group‐free synthesis using organolithium compounds and opens a new possibility in the synthesis of polyfunctional organic molecules. Microreactors: Flash chemistry using flow microreactors enables highly chemoselective reactions of difunctional electrophiles with functionalized aryllithium compounds by virtue of extremely fast micromixing. The approach serves as a powerful method for protecting‐group‐free synthesis using organolithium compounds.
Bibliography:ark:/67375/WNG-1Q9P5MZ7-4
istex:E8349F965D5506652052B00E2EEB3EDD233614CD
ArticleID:ANIE201410717
This work was partially supported by the Grant-in-Aid for Scientific Research (S) (no. 26220804) and Scientific Research (B) (no. 26288049)
This work was partially supported by the Grant‐in‐Aid for Scientific Research (S) (no. 26220804) and Scientific Research (B) (no. 26288049)
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201410717