Simplification of complex insulin regimens using canagliflozin or liraglutide in patients with well‐controlled type 2 diabetes: A 24‐week randomized controlled trial
Aims/Introduction We investigated the potential use of canagliflozin, in comparison with liraglutide, as an alternative to bolus insulin in patients with well‐controlled type 2 diabetes mellitus receiving multiple daily insulin injection therapy. Materials and Methods In 40 patients, with glycated h...
Saved in:
Published in | Journal of diabetes investigation Vol. 12; no. 10; pp. 1816 - 1826 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Japan
John Wiley & Sons, Inc
01.10.2021
John Wiley and Sons Inc Wiley |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Aims/Introduction
We investigated the potential use of canagliflozin, in comparison with liraglutide, as an alternative to bolus insulin in patients with well‐controlled type 2 diabetes mellitus receiving multiple daily insulin injection therapy.
Materials and Methods
In 40 patients, with glycated hemoglobin (HbA1c) levels <7.5% controlled by multiple daily insulin injection therapy, all bolus insulin was randomly switched to canagliflozin (100 mg/day) or liraglutide (0.3–0.9 mg/day) for 24 weeks. Basal insulin was continued with dose adjustment according to a predefined algorithm. The end‐points were the change in the HbA1c level, glycemic variability assessed by continuous glucose monitoring, body mass index, insulin dose, quality of life (QOL) and safety assessments. Factors influencing the changes in QOL were also assessed using a simple regression analysis.
Results
The change in HbA1c from baseline was comparable between the treatments. Both treatments maintained the HbA1c level to the baseline levels with stable glucose variability and no severe hypoglycemia for 24 weeks, decreased total insulin dose, and significantly increased the QOL score. The change in QOL was significantly associated with injection frequency.
Conclusions
For patients with well‐controlled type 2 diabetes mellitus, under the support of basal insulin, complex insulin regimens can be simplified by replacing all bolus insulin with once‐daily canagliflozin or liraglutide, which improves patients’ QOL.
In patients with well‐controlled type 2 diabetes mellitus, under the support of basal insulin, complex insulin regimens can be simplified by replacing all bolus insulin with once‐daily canagliflozin or liraglutide, which improves patients' quality of life. |
---|---|
Bibliography: | Clinical Trial Registry UMIN000019382 University Hospital Medical Information Network Clinical Trial Registry |
ISSN: | 2040-1116 2040-1124 |
DOI: | 10.1111/jdi.13533 |