Highly Pathogenic Reassortant Avian Influenza A(H5N1) Virus Clade 2.3.2.1a in Poultry, Bhutan

• Published in: Emerging infectious diseases Vol. 22; no. 12; pp. 2137 - 2141
• Main Authors: Marinova-Petkova, Atanaska, Franks, John, Tenzin, Sangay, Dahal, Narapati, Dukpa, Kinzang, Dorjee, Jambay, Feeroz, Mohammed M, Rehg, Jerold E, Barman, Subrata, Krauss, Scott, McKenzie, Pamela, Webby, Richard J, Webster, Robert G
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.12.2016; Centers for Disease Control and Prevention
• Subjects: Animals; Avian influenza; Avian influenza viruses; Bhutan; Bhutan - epidemiology; clade 2.3.2.1a; Disease Outbreaks; Dispatch; Genotype; Geography, Medical; highly pathogenic avian influenza H5N1; Humans; Indian subcontinent; Influenza A Virus, H5N1 Subtype - classification; Influenza A Virus, H5N1 Subtype - genetics; Influenza in Birds - epidemiology; Influenza in Birds - virology; Influenza, Human - epidemiology; International economic relations; Livestock farms; outbreak; Phylogeny; Poultry - virology; Poultry industry; reassortant; Reassortant Viruses - genetics; Risk; Bangladesh; Bhutan; India; influenza; Bhutan; viruses; avian influenza; zoonoses; ferret model: respiratory diseases; clade 2.3.2.1a; transmission; highly pathogenic avian influenza H5N1; Indian subcontinent; influenza virus; outbreak; reassortant
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2212.160611

Highly pathogenic avian influenza A(H5N1), clade 2.3.2.1a, with an H9-like polymerase basic protein 1 gene, isolated in Bhutan in 2012, replicated faster in vitro than its H5N1 parental genotype and was transmitted more efficiently in a chicken model. These properties likely help limit/eradicate outbreaks, combined with strict control measures.