Aeromonas caviae strain induces Th1 cytokine response in mouse intestinal tract

• Published in: Canadian journal of microbiology Vol. 56; no. 1; pp. 27 - 31
• Main Authors: Hayes, Samuel L, Lye, Dennis J, McKinstry, Craig A, Vesper, Stephen J
• Format: Journal Article
• Language: English
• Published: Ottawa, ON National Research Council of Canada 01.01.2010; NRC Research Press; Canadian Science Publishing NRC Research Press
• Subjects: AEROMONAS; Aeromonas - immunology; Aeromonas caviae; Animals; Bacteria; Bacteriology; BASIC BIOLOGICAL SCIENCES; Biological and medical sciences; Biological response modifiers; Cytokines; Cytokines - genetics; Cytokines - immunology; Diarrhea; Disease Models, Animal; DISEASES; DNA microarrays; Enterotoxins; expression de gènes induits par l'interféron; Female; Fundamental and applied biological sciences. Psychology; Gastrointestinal diseases; Gastrointestinal tract diseases; Gene expression; Gene Expression Regulation - immunology; GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; GENES; Gram-Negative Bacterial Infections - immunology; Health aspects; Helper cells; HEMOLYSINS; Immune response; Interferon; interferon induced gene expression; Interferon-gamma - immunology; Intestine; Intestine, Small - immunology; Intestine, Small - microbiology; Lymphocytes T; LYMPHOKINES; Mice; Microbiology; Miscellaneous; NECROSIS; NEOPLASMS; Opportunist infection; Oral infection; PATHOGENS; réponse Th1; STRAINS; Th1 Cells - immunology; Th1 response; Tumor necrosis factor-a; Tumor Necrosis Factor-alpha - immunology; Tumors; VIRULENCE; Virulence (Microbiology); virulence factors; Waterborne diseases; Waterborne infections; Canada; Digestive system; Rodentia; Cytokine; Gut; Th1 lymphocyte; Helper cell; Strain; Vertebrata; Mammalia; Gene; Mouse; T-Lymphocyte; Bacteria; Vibrionaceae; Interferon; Aeromonas punctata
• ISSN: 0008-4166; 1480-3275
• DOI: 10.1139/W09-107

Aeromonas caviae has been associated with human gastrointestinal disease. Strains of this species typically lack virulence factors (VFs) such as enterotoxins and hemolysins that are produced by other human pathogens of the Aeromonas genus. Microarray profiling of murine small intestinal extracts, 24 h after oral infection with an A. caviae strain, provides evidence of a Th1 type immune response. A large number of gamma-interferon (γ-IFN) induced genes are up-regulated as well as several tumor necrosis factor-alpha (TNF- α) transcripts. Aeromonas caviae has always been considered an opportunistic pathogen because it lacks obvious virulence factors. This current effort suggests that an A. caviae strain can colonize the murine intestinal tract and cause what has been described by others as a dysregulatory cytokine response. This response could explain why a number of diarrheal waterborne disease cases have been attributed to A. caviae even though it lacks obvious enteropathogenic properties.