Pseuduvarines A and B, Two New Cytotoxic Dioxoaporphine Alkaloids from Pseuduvaria rugosa

• Published in: Chemical & Pharmaceutical Bulletin Vol. 59; no. 7; pp. 896 - 897
• Main Authors: Taha, Hairin, Hadi, A. Hamid A., Nordin, Noraziah, Najmuldeen, Ibrahim A., Mohamad, Khalit, Shirota, Osamu, Nugroho, Alfarius E., Piow, Wong Chin, Kaneda, Toshio, Morita, Hiroshi
• Format: Journal Article
• Language: English; Japanese
• Published: TOKYO The Pharmaceutical Society of Japan 2011; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Annonaceae - chemistry; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Aporphines - chemistry; Aporphines - isolation & purification; Aporphines - pharmacology; Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; cytotoxic activity; dioxoaporphine; Drug Screening Assays, Antitumor; Humans; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Molecular Conformation; Pharmacology & Pharmacy; Physical Sciences; Plant Bark - chemistry; Plant Stems - chemistry; Pseuduvaria rugosa; pseuduvarine A; pseuduvarine B; Science & Technology; HUNTERIA-ZEYLANICA; ANNONACEAE; cytotoxic activity; pseuduvarine B; dioxoaporphine; pseuduvarine A; Pseuduvaria rugosa
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.59.896

Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC50, 0.9, 21.7, and >50.0 μM, respectively, 2: IC50 >50.0, 15.7, and 12.4 μM, respectively).