Non-opioid Analgesics and the Endocannabinoid System

Non-steroidal anti-inflammatory drugs produce antinociceptive effects mainly through peripheral cyclooxygenase inhibition. In opposition to the classical non-steroidal anti-inflammatory drugs, paracetamol and dipyrone exert weak anti-inflammatory activity, their antinociceptive effects appearing to...

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Bibliographic Details
Published inBalkan medical journal Vol. 37; no. 6; pp. 309 - 315
Main Authors Topuz, Ruhan Deniz, Gündüz, Özgur, Karadağ, Çetin Hakan, Ulugöl, Ahmet
Format Journal Article
LanguageEnglish
Published Galenos Yayinevi Tic. Ltd 01.11.2020
Trakya Üniversitesi
Galenos Publishing
Galenos Publishing House
Subjects
Acetaminophen
dipyrone
Endocannabinoids
Health aspects
Invited Review
Nonsteroidal anti-inflammatory agents
nsaids
paracetamol
Physiological aspects
Tıp
Turkey
Türkiye
Edirne
Dipyrone
endocannabinoids
paracetamol
NSAIDs
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Summary:Non-steroidal anti-inflammatory drugs produce antinociceptive effects mainly through peripheral cyclooxygenase inhibition. In opposition to the classical non-steroidal anti-inflammatory drugs, paracetamol and dipyrone exert weak anti-inflammatory activity, their antinociceptive effects appearing to be mostly due to mechanisms other than peripheral cyclooxygenase inhibition. In this review, we classify classical non-steroidal anti-inflammatory drugs, paracetamol and dipyrone as "non-opioid analgesics" and discuss the mechanisms mediating participation of the endocannabinoid system in their antinociceptive effects. Non-opioid analgesics and their metabolites may activate cannabinoid receptors, as well as elevate endocannabinoid levels through different mechanisms: reduction of endocannabinoid degradation via fatty acid amide hydrolase and/or cyclooxygenase-2 inhibition, mobilization of arachidonic acid for the biosynthesis of endocannabinoids due to cyclooxygenase inhibition, inhibition of endocannabinoid cellular uptake directly or through the inhibition of nitric oxide synthase production, and induction of endocannabinoid release. Keywords: Dipyrone, endocannabinoids, NSAIDs, paracetamol
Bibliography:ObjectType-Article-1
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ISSN:2146-3123
2146-3131
DOI:10.4274/balkanmedj.galenos.2020.2020.6.66